By KTEL bus
From Kifisos bus station, buses run hourly to Xylokastro (~2 hours). From there, a connecting bus to Trikala runs Monday, Wednesday and Friday (08:15 and 14:00), taking about an hour.
Bus schedule
By bus (KTEL)
No car? There's a way to get here — KTEL from Athens, via Xylokastro.